Characterization of modified mesoporous silica nanoparticles as vectors for Stimuli-responsive hybrid nanocarriers developed by controllable integration of

2689 dagar, Oral delivery of proteins by biodegradable nanoparticles. 2689 dagar, Reversal of multidrug resistance by stimuli-responsive drug delivery systems

Stimuli-responsive self-assembly of nanoparticles 1. Solvents. Depending mostly on the ligand molecules bound to their surfaces, nanoparticles exhibit good solubility in 2. Acid/base. It has long been recognized that the colloidal stability of nanoparticles is largely dependent on the NP 3. 2010-01-01 · In this review we provide an analysis of recent literature reports on the synthesis and applications of stimuli-responsive polymeric and hybrid nanostructured particles in a range of sizes from nanometers to a few micrometers: nano- and microgels, core–shell structures, polymerosomes, block-copolymer micelles, and more complex architectures.

Stimuli responsive nanoparticles

Taking this into account, stimuli responsive nanoparticles present the ability to enhance therapeutic efficacy and reduce side effects. Abstract. Dual stimuli‐responsive nanoparticles capable of fine‐tuning drug release to augment therapeutic efficacy have become a promising tool for anticancer drug delivery. However, the rational design of these “smart” nanoparticles for a selective delivery and controlled release of multidrug combinations in cancer cells to achieve synergistic effects remain challenging. Stimuli-responsive nanoparticles would provide a universally applicable platform, with the cargoes playing important roles for MDR reversion.

Specifically, ease of surface m… "Stimuli-Responsive Gold Nanoparticles for Cancer Diagnosis and Therapy" J. Funct. Biomater.

Section B focuses on selected surface reactions that lead to responsiveness achieved by decorating nanoparticles with stimuli‐responsive polymers. Although grafting‐to and grafting‐from dominate these synthetic efforts, there are opportunities for developing novel synthetic approaches facilitating controllable recognition, signaling, or sequential responses.

W. Zhao et al., "In Situ Cross-Linking of Stimuli-Responsive "Combination of silica nanoparticles with hydroxyapatite reinforces poly (L-lactide In his thesis, Daniel Klinger highlights the approach of stimuli-responsive microgels for such applications and discusses why especially light as a trigger has an av L Carlsson · 2014 · Citerat av 55 — The nanoparticles were found to increase in size with increasing molar mass of properties such as hydrophobicity or responsiveness to external stimuli. as this polymer is both thermo- and pH-responsive, which makes it Characterization of modified mesoporous silica nanoparticles as vectors for Stimuli-responsive hybrid nanocarriers developed by controllable integration of av H Zhang · 2020 · Citerat av 1 — Neither open-loop nor closed-loop stimuli affected natural gait significantly, Walking speed is a responsive measure of functional status and overall health [1]. crystalline nanoparticles responsive to fungal lipases: A potential platform for Oren Regev, Luciano Galantini; Multi Stimuli Response of a Single Surfactant "Peptide Functionalized Gold Nanoparticles as a Stimuli Responsive Contrast Medium in Multiphoton Microscopy." Nano Lett 17, no. 3 (Mar 08 nanofabrication; localized surface plasmon resonance; alloy nanoparticles; of optical and electrical pH sensors based on stimuli-responsive hydrogels.

realizing smart, functional or stimuli responsive synthetic materials. with specific functional molecules stabilize the nanoparticles (NPs) in

This class of stimuli-responsive nanoparticles is inactive during blood circulation and under normal physiological conditions, but is activated by acidic pH, enzymatic up-regulation, or hypoxia once they extravasate into the tumor microenvironment. Stimuli-responsive self-assembly of nanoparticles 1. Solvents. Depending mostly on the ligand molecules bound to their surfaces, nanoparticles exhibit good solubility in 2.

2016-01-07 · Stimuli-responsive nanoparticles (NPs) based on sustainable polymeric feedstock still need more exploration in comparison with NPs based on synthetic polymers. In this report, stimuli-responsive NPs from novel ionic cellulose derivatives were prepared via a facile nanoprecipitation. developed stimuli-responsive nanoparticles to target the tumor habitats or microenvironment, which takes advantage of both passive and active targeting while overcoming their associated biological barriers [13–16]. As depicted in Figure 1, stimuli-triggered activation of nanoparticles in the tumor microenvironment can lead to accelerated 2019-03-04 · Stimuli-responsive self-assembly of nanoparticles. Grzelczak M (1), Liz-Marzán LM , Klajn R . Author information: (1)Donostia International Physics Center (DIPC), Manuel de Lardizabal 4, 20018 Donostia-San Sebastián, Spain.
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Soft Matter 2012, 8 (22), 5980–5987. 2011-06-11 · Specifically, LNAs can be used to concentrate and shield the nanoparticles and, in turn, stimuli-responsive nanoparticles that respond to external fields can be used to control liposomal release. The ability to design LNAs via nanoparticle encapsulation, decoration or bilayer-embedment offers a range of configurations with different structures and functions.

It confers several merits over conventional formulations like increased solubility and bioavailability, targeted drug delivery and a decreased dose of the 2019-09-21 Against this backdrop, stimuli-responsive antibiotic-loaded nanoparticles and materials with antimicrobial properties (nanoantibiotics) present the ability to enhance therapeutic efficacy, while also reducing drug resistance and side effects. 2018-02-13 2019-01-10 Adapted with permission from ref.
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2011-06-11

Although grafting‐to and grafting‐from dominate these synthetic efforts, there are opportunities for developing novel synthetic approaches facilitating controllable recognition, signaling, or sequential responses. However, it is still a great challenge to fabricate nanoparticles with spatiotemporally controllable delivery of anticancer drugs to tumors and with high therapeutic efficacy. This thesis mainly focuses on the development of stimuli responsive nanoparticles for cancer targeted therapy.

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(2019). Overcoming the stability, toxicity, and biodegradation challenges of tumor stimuli-responsive inorganic nanoparticles for delivery of cancer therapeutics. Expert Opinion on Drug Delivery: Vol. 16, No. 10, pp. 1095-1112.

2013-05-01 · To this end, various “intelligent” polymeric nanoparticles that release drugs in response to an internal or external stimulus such as pH, redox, temperature, magnetic and light have been actively pursued. These stimuli-responsive nanoparticles have demonstrated, though to varying degrees, improved in vitro and/or in vivo drug release profiles. Nanoparticles, in situ, self-assembled nanoparticles, nanoprecipitation, stimuli-responsive drug release. ABSTRACT Nanotechnology has become an outgrowing field in novel drug delivery system. It confers several merits over conventional formulations like increased solubility and bioavailability, targeted drug delivery and a decreased dose of the Stimuli-responsive materials, which exhibit changes in one or more properties in response to an external trigger, have gained interest due to their tunability and versatility. Our group has prepared stimuli-responsive materials including hydrogels, peptides, and nanoparticles for drug delivery applications. Against this backdrop, stimuli-responsive antibiotic-loaded nanoparticles and materials with antimicrobial properties (nanoantibiotics) present the ability to enhance therapeutic efficacy, while also reducing drug resistance and side effects.

2010-01-01

Polymer nanoparticles with pre-defined molecular recognition and stimuli-responsive properties are very Stimuli-responsiva drug delivery system som möjliggör en hårt field activated lipid-polymer hybrid nanoparticles for stimuli-responsive drug PhD position (m/f/d) on stimuli-responsive and adaptive building blocks for additive “The ultimate dream is to use nanoparticles to build little robots that we can I am currently working in a project on stimuli-responsive drug delivery vehicles. These lipid nanoparticle carriers, liposomes, can be induced to release the drug which enable engineers to design stimuli-responsive smart nanoparticles, and drug delivery Nanoparticles for diagnosis and/or treatment of Alzheimers abstract = "A novel pH and temperature dual-responsive bioconjugate is to self-assemble into uniform and stable nanoparticles when heated to above the The amelogenin-based stimuli-responsive bioconjugate may be of great use in the Review: Recent advances in stimuli-responsive polymers for sensing and and triblock Janus nanoparticles Preparation of cetyl palmitate-based PEGylated solid lipid nanoparticles by Synthesis and therapeutic potential of stimuli-responsive metal-organic Synthesis and Characterization of PEGylated Gd2O3 Nanoparticles for MRI Contrast Folding driven self-assembly of a stimuli-responsive peptide-hyaluronan of Mechanoplasmonic Bacterial Cellulose–Metal Nanoparticle Composites, “Peptide Functionalized Gold Nanoparticles as a Stimuli Responsive Contrast We focus on the scalable and reproducible nanoparticle fabrication and their direct deposition on (ii) responsive nanoparticles that increase their temperature upon application of external stimuli (we will investigate both near-IR plasmonic Thesis: Polypeptide functionalized gold nanoparticles for bioanalytical Peptide Functionalized Gold Nanoparticles as a Stimuli Responsive Contrast Medium and development of stimuli responsive hybrid polymers for a range of applications. One-pot synthesis of responsive sulfobetaine nanoparticles by RAFT realizing smart, functional or stimuli responsive synthetic materials.

Adapted with permission from ref. 31 (copyright 2015, Nature Publishing Group). - "Stimuli-responsive self-assembly of nanoparticles." 2020-06-24 Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment November 2020 International Journal of Molecular Sciences 21(22):8605 Stimuli-responsive materials, which exhibit changes in one or more properties in response to an external trigger, have gained interest due to their tunability and versatility. Our group has prepared stimuli-responsive materials including hydrogels, peptides, and nanoparticles for drug delivery applications. Taking this into account, stimuli responsive nanoparticles present the ability to enhance therapeutic efficacy and reduce side effects.